Caspase 8

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

Also Known As:

Caspase-8; CAP4 Protease; FLICE Protein; MACH Protein; Mch5 Protease; Pro-Caspase-8; Procaspase-8; Pro Caspase 8; Procaspase 8

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Cysteine Proteases: 1964
        Cysteine Endopeptidases: 4
        Caspases: 9379
        Initiator Caspases: 34
        Caspase 8: 2442
      - Endopeptidases: 633
        Cysteine Endopeptidases: 4
        Caspases: 9379
        Initiator Caspases: 34
        Caspase 8: 2442
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Signal Transducing Adaptor Proteins
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Caspase 8: 2442
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - Caspases: 9379
        Initiator Caspases: 34
        Caspase 8: 2442
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Caspase 8: 2442
    - Signal Transducing Adaptor Proteins
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Caspase 8: 2442

E Appel Selected Research

E Appel Research Topics

Disease

Drug/Important Bio-Agent (IBA)